TABLE 2.

Summary of studies reported up‐regulation of SAMMSON in clinical samples.

Clinical samples	SAMMSON expression	Association with clinical data	Kaplan Meier	AUC	Refs
90 Paired tissues, 90 OSCC patient serum and 40 normal healthy controls	Up	Significant association with the clinical stages, Distant & Lymph node metastasis, Cancer invasion depth and Differentiation.	High SAMMSON expression significantly associated with poor overall survival and disease‐free survival	0.74 for OSCC serum samples vs healthy serum controls.	34
126 Paired tissues of GC	Up	Significant association with the clinical stages, distant metastasis and lymph node metastasis	High SAMMSON expression significantly associated with FS & OS	‐	24
70 Paired tissues and plasma of PTC	Up	Significant association with the clinical stages, Lymph node metastasis, and tumour size	High SAMMSON expression significantly associated with shorter overall and disease‐free survival time	0.91 for PTC plasma samples vs healthy controls	27
67 Malignant melanoma and 11 nevi tissues	Up	‐	Lower SAMMSON expression is associated with increased 10‐year OS	‐	17
40 Paired tissues of GC	Up	Significant association with the tumour grade & tumour size	‐	‐	31
56 GBM, and 35 control & 34 patients with DN	Up	‐	‐	0.88 for GBM vs control and 0.92 for GBM vs ND	26
68 TNBC Paired tissues	Up	Significant association with the clinical stages	‐	‐	23
70 Paired tissues of HCC	Up	‐	Patients with high levels of SAMMSON in HCC tissues had significantly lower overall rate	‐	13

Abbreviations: AUC, area under the curve; FS, Free survival; ND, neurosarcoidosis; OS, overall survival; OSCC, oral squamous cell carcinoma; TNBC, triple‐negative breast cancer; UP, upregulation.