Table 3.
Mean difference in anxiety and depression symptoms by baseline severity category. Patients with at least mild baseline symptoms (baseline GAD-7a or PHQ-8b scores≥5) are included in the analyses.
| Measure and baseline severity | Responses, n (%) | Baseline score, mean (SD) | Last score, mean (SD) | Changes from baseline (%) | Mean difference (95% CI) | Baseline score, median | Last score median | Kruskal-Wallis (df) | P value | ||||||||||||
| GAD-7 (n=1602) | 336.85 (2) | <.001 | |||||||||||||||||||
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Mild anxiety (5-9) | 528 (32.96) | 7.09 (1.39) | 4.55 (3.42) | 35.83 | –2.54 (–2.84 to –0.24) | 7 | 4 |
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Moderate anxiety (10-14) | 541 (33.77) | 11.91 (1.37) | 6.79 (4.08) | 42.99 | –5.12 (–5.47 to –4.77) | 12 | 6 |
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Severe anxiety (≥15) | 533 (33.27) | 17.57 (1.88) | 9.24 (5.51) | 47.41 | –8.33 (–0.81 to –7.86) | 17 | 8 |
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| PHQ-8 (n=1572) | 304.6 (3) | <.001 | |||||||||||||||||||
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Mild depression (5-9) | 475 (30.22) | 7.15 (1.34) | 4.93 (4.01) | 31.05 | –2.22 (–2.59 to –1.86) | 7 | 4 |
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Moderate depression (10-14) | 530 (33.72) | 11.97 (1.40) | 6.68 (4.61) | 44.19 | –5.29 (–5.80 to –4.90) | 12 | 6 |
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Moderately severe depression (15-19) | 394 (25.06) | 16.91 (1.39) | 9.08 (5.94) | 46.30 | –8.83 (–8.41 to –7.24) | 17 | 8 |
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Severe depression (≥20) | 173 (11.01) | 21.36 (1.31) | 11.95 (6.13) | 44.05 | –9.41 (–10.31 to –8.51) | 21 | 12 |
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aGAD-7: Generalized Anxiety Disorder–7.
bPHQ-8: Patient Health Questionnaire–8.