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. 2023 Nov 30;11(12):1792. doi: 10.3390/vaccines11121792

Figure 1.

Figure 1

Time course of platelet, PT, and APTT levels after single IV or IM dosing with Ad26-based vaccines in rabbits. Levels of (A) platelet counts, (B) PT, and (C) APTT were measured in plasma taken at the indicated time points pre- and post-dosing with vehicle IV (V1); vehicle IM (V2); Ad26.COV2.S IV at 0.2 × 109 vp/kg (A1), 1 × 109 vp/kg (A2), or 5 × 109 vp/kg (A3); Ad26.COV2.S IM at 5 × 109 vp/kg (A4); Ad26.ZIKV.001 IV at 5 × 109 vp/kg (B1); Ad26.ZIKV.001 IM at 5 × 109 vp/kg (B2); or MMR IV (C). The time course of each parameter is shown, with lines representing the group mean and symbols corresponding to individual animals (n = 5/group) for each time point evaluated. The left graphs in each panel show the data from groups V1, V2, C, A1, and A2. The right graphs in each panel show the data from groups A3, A4, B1, and B2. APTT, activated partial thromboplastin time; IM, intramuscular; IV, intravenous; MMR, measles–mumps–rubella; PT, prothrombin time; vp, viral particles.