Table 1.
Amino acid differences in the neutralizing epitope regions of the VP7 gene segment between Rwandan G9P[8] study strains and rotavirus vaccine strains. The colored shading is used to indicate amino acid differences that were observed. The array of colored shading of the amino acid residues for the vaccine strains represents changes that were observed when comparing the G9P[8] study strains to these vaccine strains.
| Neutralisation Epitopes | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7-1a | 7-1b | 7-2 | ||||||||||||||||||||||||||||
| 87 | 91 | 94 | 96 | 97 | 98 | 99 | 100 | 104 | 123 | 125 | 129 | 130 | 291 | 201 | 211 | 212 | 213 | 238 | 242 | 143 | 145 | 146 | 147 | 148 | 190 | 217 | 221 | 264 | ||
| Vaccine strains | RVA/Vaccine/USA/RotaTeq-WI79-9/1992/G1P75 | T | T | N | G | D | W | K | D | Q | S | V | V | D | K | Q | N | V | D | N | T | K | D | Q | S | L | S | M | N | G |
| RVA/Vaccine/USA/RotaTeq-WI79-9/1992/G2 | A | N | S | D | E | W | E | N | Q | D | T | M | N | K | Q | D | V | S | N | S | R | D | N | T | S | D | I | S | G | |
| RVA/Vaccine/USA/RotaTeq-WI79-9/1992/G3 | T | T | N | N | S | W | K | D | Q | D | A | V | D | K | Q | D | A | N | K | D | K | D | A | T | L | S | E | A | G | |
| RVA/Vaccine/USA/RotaTeq-WI79-9/1992/G4 | S | T | S | T | E | W | K | D | Q | N | L | I | D | K | Q | D | T | A | D | T | R | A | S | G | E | S | T | S | G | |
| RVA/Vaccine/USA/Rotarix-A41CB052A/1988/G1P1A8 | T | T | N | G | E | W | K | D | Q | S | V | V | D | K | Q | N | V | D | N | T | K | D | Q | N | L | S | M | N | G | |
| RVA/Vaccine/IND/Rotavac-116E/AG/G9P[11] | I | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | N | S | T | L | S | E | N | G | |
| RVA/Vaccine/IND/Rotasill-Au32/2016/G9 | A | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | T | K | D | S | T | L | S | E | S | G | |
| Pre- vaccination strains | RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1618/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1616/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1589/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1586/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1584/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1577/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1573/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1567/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1550/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU1534/2011/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU541/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU471/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU464/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU425/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU413/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU240/2012/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU238/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU226/2012/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU222/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU214/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU213/2012/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU210/2012/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/NGS-UFS-MRC-DPRU229/2012/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| Post- vaccination strains | RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU615/2013/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU543/2013/G9P[8] | T | T | G | T | E | W | K | G | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU433/2013/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU8058/2015/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | S | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU8039/2015/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | S | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU10026/2015/G9P[8] | T | T | G | T | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | S | K | D | S | T | L | S | E | S | G | |
| RVA/Human-wt/RWA/UFS-NGS-MRC-DPRU8031/2015/G9P[8] | T | T | G | A | E | W | K | D | Q | D | A | I | D | K | Q | N | T | A | D | N | K | D | S | T | L | S | E | S | G | |