A2E |
Bis-retinoid N-retinyl-N-retinylidene ethanolamine |
AMD |
Age-related macular degeneration |
APOE |
Apolipoprotein E |
ARMS2 |
Age-related maculopathy susceptibility 2 |
AREDS |
Age-Related Eye Disease Study |
ARE |
Anti-oxidant response element |
ATP |
Adenosine tri phosphate |
BDNF |
Brain-derived neurotrophic factor |
C3 |
Complement factor 3 |
C4 |
Complement factor 4 |
C5 |
Complement factor 5 |
C5-9 |
Membrane attack complex |
C9 |
Complement factor 9 |
CFH |
Complement factor H |
CFHR1 |
Complement factor H related 1 |
CFHR5 |
Complement factor H related 5 |
CCR2 |
Receptor for CCL2 |
CCL2 |
Monocyte chemotactic protein-1 (MCP-1) |
CD36 |
Scavenger receptor recognizes oxidized phospholipids and lipoproteins |
CEP |
2-(ω-carboxyethyl) pyrrole |
CNS |
Central nervous system |
CNV |
Choroidal neovascularization |
CRP |
C-reactive protein |
CTGF |
Connective tissue growth factor |
CX3CL1 |
Fractalkine |
CX3CR1 |
Fractalkine receptor |
Cyba |
Cytochrome b245 Alpha |
Cybb |
Cytochrome b245 Beta |
FUT5 |
Alpha-(1,3)-fucosyltransferase |
GA |
Geographic atrophy |
GDNF |
Glial-cell-derived neurotrophic factor |
HTRA1 |
High-temperature requirement A serine peptidase 1 |
HDLs |
High-density lipoproteins |
Keap1 |
Kelch-like ECH- associated protein 1 |
LPS |
Lipopolysaccharide |
M0 |
Resting macrophage/microglia |
M1 |
Proinflammatory/phagocytic/classically activated macrophage microglia |
M2a |
Anti-inflammatory/profibrotic/alternatively activated macrophage/microglia |
M2b |
Profibrotic/alternatively activated macrophage/microglia |
M2c |
Healing/resolution/anti-inflammatory/anti-fibrotic alternatively activated macrophage/microglia |
M2d |
Angiogenic/VEGF producing alternatively activated macrophage/microglia |
MCP-1 |
Monocyte Chemotactic Protein-1 |
MDA |
Malondialdehyde |
MPS |
Mononuclear phagocyte series |
NCAM |
Neural cell adhesion molecule |
NLRP3 |
NOD-, LRR- and pyrin domain-containing protein 3 |
NOS2 |
Nitric oxide synthase 2 |
NRF2 |
Nuclear factor erythroid 2 |
PBMC |
Peripheral blood-derived macrophage |
PBMDMs |
Peripheral blood monocytes-derived macrophages |
PD-L1 |
Programmed death-ligand 1 |
POS |
Photoreceptor outer segment |
PSA |
Polysialic acid |
OCT |
Optical coherence tomography |
ROS |
Reactive oxygen species |
RPE |
Retinal pigment epithelium |
SAP |
Serum amyloid P |
sSAMP |
Sialic acid self-associated molecular pattern |
SAMP |
Self-associated molecular pattern |
Siglecs |
Sialic acid-binding immunoglobulin-like lectins |
ST6GALNAC1 |
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
ST6 |
ST6GALNAC1 |
TGF-B |
Transforming growth factor beta |
TLR |
Toll-like receptor |
TREM2 |
Triggering receptor expressed on myeloid cells 2 |
VEGF |
Vascular endothelial growth factor |