Table 1.

Summary of ItP-mediated delivery of various macromolecules.

Author	Macromolecules	Study Model & and Dose of IP	Outcome
Kigasawa et al. [52]	IL-10 siRNA	Atopic dermatitis rat; 0.3 mA/cm2, for 1 h	ItP-induced intradermal delivery of siRNA and reduced IL-10 mRNA expression.
Hasan et al. [44]	HSP47 siRNA	CCl4-induced fibrosis mice; 0.34 mA/cm2, 30 min	ItP-induced hepatic delivery of siRNA and significantly suppressed HSP 47 mRNA expression as well as pathogenesis of fibrosis.
Hasan et al. [44]	Resistin siRNA	KKAy obesity model mice; 0.34 mA/cm2, 30 min	ItP of siRNA significantly suppressed resistin expression and hepatic lipid accumulation.
Hasan et al. [44]	Pdx-1 siRNA	BALB/c mice, 0.34 mA/cm2, 30 min	Significantly suppressed Pdx-1 expression in pancreas.
Jose et al. [54]	Liposome-encapsulated STAT3 siRNA and curcumin	Murine model of melanoma; 0.47 mA/cm2, 2 h	ItP-mediated co-delivery showed potent tumor suppression relative to single applications.
Kigasawa et al. [57]	Liposomal superoxide dismutase	UV-irradiated Rats; 0.45 mA/cm2, 1 h	ItP-mediated delivery of SOD reduced UV-induced skin damage.
Kajimoto et al. [61]	Liposome-encapsulated insulin	Diabetic rats 0.45 mA/cm2, 1 h	Stably maintained the blood glucose level up to 24 h.
Boinpally et al. [65]	Liposomes-encapsulate cyclosporin A	Human cadaver epidermis (in vitro); 0.57 mA/cm2, 5 h	ItP-mediated intradermal delivery of cyclosporin A will be useful for local immunosuppression.
Fukuta et al. [70]	TNF-α drugetanercept	IMQ-induced psoriasis rat; 0.34 mA/cm2, 1 h	ItP significantly reduced the epidermal hyperplasia and pathogenesis of psoriasis.
Lapteva et al. [71]	Cetuximab	Porcine skin; 0.5 mA/cm2, 2, 4, 8 h	ItP-employed intradermal delivery of cetuximab.