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. 2023 Dec 13;15(12):2419. doi: 10.3390/v15122419

Figure 5.

Figure 5

Association of NLRP3 inflammasome basal expression and ex vivo reactivation with 28-day mortality in septic patients. Percentages of ASC speck-positive monocytes and MFI of FAM-FLICA in PMN were assessed in septic patients (n = 32) within the first 48 h of hospitalization (D0, n = 27), between days 3–5 (D3, n = 26), and between days 6–9 (D7, n = 13). This was conducted under basal conditions (A) and following ex vivo stimulation with nigericin at 10 µg/mL for 30 min (B). Patients were stratified based on their 28-day status: survivors (n = 21, in grey) or non-survivors (n = 9, in red). Missing data points relate to patients with unknown 28-day statuses (n = 2). Results are expressed as individual values and boxplots. The dotted black line indicates the median value observed in healthy volunteers for the respective parameter. The Mann–Whitney non-parametric test was used for comparison between survivors and non-survivors. * p < 0.05.