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Patients’ enrollment and random assignment. Screening exclusions at registration included women who were human papillomavirus-16 negative and those not diagnosed with cervical intraepithelial neoplasia 2 or 3 by central pathology (*). The remaining 165 patients were enrolled and participated in a double-blind random assignment. A total of 165 patients were assigned to all groups, and 3 patients were discontinued from the study.
