FIGURE 3.

Sweat EVs exhibit specific metabolic qualities. (A). Metabolite signatures of the amino acid pathway including (alanine, arginine, glycine, lysine, proline, serine, threonine, and tyrosine). (B). Metabolite signatures of glutathione and glutamate pathways. The metabolites are pyroglutamate, glutamate, and glutamine. (C). Metabolite signatures of the fatty acid pathway. The metabolites are palmitate and myristate. (D). Metabolite signatures of the creatine pathway. The metabolites are creatine, creatinine, and carnitine. (E). Metabolite signatures of glycolysis pathway including lactate. Data are metabolite peak area fold changes ±SEM after normalization to the total EVs concentrations (particles/mL) and to the negative control (patch without sweat sample). N = 10; three women and seven men.