FIGURE 5.

Metabolites from sweat EVs may mirror metabolic variances during the exercise test when compared to recovery state in healthy individuals. Metabolite levels of threonine (A), serine (B), lactate (C), and pyroglutamate (D). Data are metabolite peak area fold changes ±SEM after normalization to the total EVs concentrations and to the negative control. Two-tailed Student’s t-test was used in A (**p = 0.046), in B (*p = 0.013), and in C (**p = 0.002), in C (ns. not significant, p = 0.07). N = 10; three women and seven men.