Hukku 1991.

Methods	Location of trial: India. Number of centres: 1. Funding: not stated. Trial ID: not stated.
Participants	Inclusion criteria: histologically proven squamous cell carcinoma, T3‐4, N0‐3, with primary tumours in oral cavity, oropharynx, larynx and nasopharynx. Exclusion criteria: chronic medical problems and distant metastases. Recruitment period: January 1980 to August 1983. OC: 7/110 (6%). OP: 72/110 (65%). OC+OP: 79/110 (70%). Number randomised: 110. Number analysed: 110.
Interventions	Split course radiotherapy versus accelerated radiotherapy Split course (n = 50): Phase 1: 15 fractions of 2.3 Gy over 3 weeks to primary tumour and bilateral neck. 2‐week break. Phase 2: 2.5 Gy per fraction for 10 fractions over 2 weeks to primary tumour and residual lymphatic disease if present or upper neck if lymph nodes not palpable. Conventional (n = 60): 4 Gy per fraction in 2 opposing fields, 5 fractions per week, total of 11 fractions and 44 Gy. Treatment delivered to primary tumour along with bilateral neck with reduction of neck field after 7 fractions.
Outcomes	Primary: locoregional control. Secondary: overall survival, disease free survival, toxicity. Duration of follow‐up: 2 years.
Notes	Dichotomous data only; unable to calculate HR.
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	"Randomisation of patients...". No details of method of sequence generation provided.
Allocation concealment?	Unclear risk	Insufficient information.
Blinding ‐ Outcome Assessors	High risk	Not mentioned.
Incomplete outcome data addressed?	Low risk	All randomised patients included in the outcome analyses.
Free of selective reporting?	Low risk	Important outcomes of overall survival, disease free survival, locoregional control and adverse events reported.
Free of other bias?	Low risk	Groups appear similar at baseline. No other apparent bias.