Fig. 5.

YTHDC2 knockdown impairs HCC ferroptosis in vivo. A Images at the end points of Huh7 cell-derived subcutaneous xenograft tumors in BALB/c nude mice. B–C Changes in tumor volume and mouse body weight in each group during the whole experimental cycle. D-F Immunohistochemistry was used to detect the protein expression in tumor tissues (scale bar: 50 μM). G Weight of tumors in each group at the end points of xenograft tumors. H-J The level of GSH, MDA and iron in tumor tissues of each group. The mean ± SD was used as the value of five independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001.