Figure 1.

Schematic representation of how polyphenols might combat glycative stress in the brain.

During hyperglycemia, sugar or its metabolites interact with biomolecules to form toxic AGEs. AGEs contribute to protein aggregation, a characteristic hallmark of neurodegenerative diseases. Polyphenols act as natural antioxidants diminishing the AGEs production and stimulating p62-selective autophagy that speeds up the AGEs clearance. Created with Microsoft PowerPoint. Drawings have been obtained from free vectors belonging to the website https://freepik.es and from the website https://smart.servicer.com/category/general-items/food.