Table 5.
The prediction and validation of novel (potential) DTIs
| Rank | Drug ID | Drug Name | Target ID | Target Name | Evidence |
|---|---|---|---|---|---|
| 1 | DB00502 | Haloperidol | P08172 | CHRM2 | DrugBank5.0 (DB00334),KEGG (hsa04080) |
| 2 | DB01136 | Carvedilol | P35368 | ADRA1B | DrugBank5.0 (Proved) |
| 3 | DB01280 | Nelarabine | Q02880 | TOP2B | Unknown |
| 4 | DB00418 | Secobarbital | P47870 | GABRB2 | DrugBank5.0 (DB06716), KEGG (hsa04080) |
| 5 | DB00398 | Sorafenib | Q08345 | DDR1 | Unknown |
| 6 | DB01236 | Sevoflurane | O60391 | GRIN3B | DrugBank5.0 (DB01520), KEGG (hsa04080) |
| 7 | DB00734 | Risperidone | P08173 | CHRM4 | DrugBank5.0 (DB09167), KEGG (hsa04080) |
| 8 | DB00370 | Mirtazapine | Q9NYX4 | CALY | DrugBank5.0 (DB00370), KEGG (hsa04080) |
| 9 | DB01159 | Halothane | P18505 | GABRB1 | DrugBank5.0 (Proved) |
| 10 | DB00449 | Dipivefrin | P25100 | CHRM2 | KEGG (Proved) |