Skip to main content
. 2023 Dec 7;99:104903. doi: 10.1016/j.ebiom.2023.104903

Fig. 4.

Fig. 4

BA.5 infection in vaccinated individuals generates higher level of BA.5 Nabs with obvious immune imprinting than unvaccinated individuals. (A) Comparison of Nabs titers against WT and BA.5 between BA.5 infection in unvaccinated and vaccinated individuals (n = 7 at D14 in the unvaccinated individuals, n = 24 at D14 in the vaccinated individuals, n = 10 at 1 M in the unvaccinated individuals, n = 23 at 1 M in the vaccinated individuals). (B) The ratios of Nabs between WT and BA.5 were analyzed in unvaccinated and vaccinated individuals. (C) Nabs titers against WT, BA.5, and XBB.1.9.1 at D0, D3, D7, D14, 1 M, 3 M, and 4 M post-BA.5 infection (n = 11 at D0, n = 7 at D3, n = 16 at D7, n = 24 at D14, n = 23 at 1 M, n = 30 at 3 M, n = 32 at 4 M). (D) Longitudinal analysis of 16 individuals to investigate the evolution of host humoral immunity from two doses of inactivated vaccine to three doses vaccination, to BA.5 infection, and then to XBB reinfection for WT Nabs. The Mann–Whitney test was employed for comparing central tendencies of every two groups, ns, not significant, ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001.