Microbiota-centered interventions. The microbiota is influenced by interventions on the quantity and quality of macronutrients, such as ketogenic diet, dietary fibers, and polyphenols. Specific bacteria in the gut may have oncoprotective effects on the production of specific metabolites and the stimulation of immunosurveillance, for instance, by the induction of crossreactive immune responses or by stimulation of Toll-like receptor 2 (TLR2). Note that the anticancer effects of Eisenbergiella are still hypothetical as indicated by the question mark. Prot, protein.