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. 2024 Jan 1;14(1):96–115. doi: 10.7150/thno.89247

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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A series of alternating copolymers “PHTA” featured with ortho-hydroxy tertiary amine (HTA) repeating units for mRNA vaccine delivery in cancer therapy. (A-C) Design of the PHTA polymers for mRNA vaccine delivery. (D) Size distribution and (E) zeta potential of PHTA-Cn/mOVA before and after OVA mRNA encapsulation. (F) Representative TEM image of PHTA-based polymeric nanoparticle (PNP). (G) Agarose gel electrophoresis images of PHTA-Cn/mOVA on day 1 and day 8 post OVA mRNA encapsulation. Adapted with permission from ¹⁰³. Copyright 2023, Wiley-VCH GmbH.