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. Author manuscript; available in PMC: 2023 Dec 26.
Published in final edited form as: Leukemia. 2022 Dec 22;37(3):560–570. doi: 10.1038/s41375-022-01798-5

Figure 3. Flt3-ITD AML alters the BM microenvironment and increases CXCL12 expression in CAR cells.

Figure 3.

(A) CXCR4 positivity in BM HSPC from Flt3-ITD vs Flt3-ITD TET2-KO mice. (B) Transplant scheme for CXCL12-GFP mice. (C) Frequencies of endothelial cells, PAC, and CAR cells within CD45-Ter119-population (left) and percentage GFP (CXCL12) positivity in endothelial, PAC, and CAR cell populations (right) in CXCL12-GFP mice transplanted with WT vs. Flt3-ITD TET2-KO AML cells. Significance values: *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001; ns, not significant. Results represent mean ± SEM of multiple replicates.