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YAP signaling related mechanisms in regulation of ferroptosis. Drugs such as erastin and sorafenib directly target cystine transporter and trigger ferroptosis. Activation of YAP induce ferroptosis by upregulating the expression of ACSL4 and TRFC. Other regulators of YAP mediated ferroptosis include NOX2, NOX4, ALOXES3 and cytoglobin. Glutamate-induced O-GlcNAcylation of YAP inhibit ferroptosis. YAP signaling suppress ferroptosis by targeting SLC7A11 and ferritin light chain.
