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. 2024 Jan 1;20(1):231–248. doi: 10.7150/ijbs.86317

Figure 3.

Figure 3

Importance of TNS4 in maintaining the stability of the integrin α5β1 complex and regulating FAK/PI3K/Akt signaling pathway. (A-C) Interactions among TNS4, integrin α5, and integrin β1. (D-E) Impact of TNS4 depletion on the interaction between integrin α5 and integrin β1. (F-G) Influence of TNS4 overexpression on the interaction between integrin α5 and integrin β1. (H-I) Effect of TNS4 depletion or overexpression on the expression levels of p-FAK, FAK, p-PI3K, PI3K, p-Akt, and Akt. (J) Expression of p-FAK, FAK, p-PI3K, PI3K, p-Akt, Akt, PCNA, E-cadherin, N-cadherin, and vimentin in HNSCC cells subjected to indicated treatments.