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. 2024 Jan 1;20(1):231–248. doi: 10.7150/ijbs.86317

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TNS4 is upregulated under the hypoxia microenvironment and transcriptionally regulated by HIF-1α. (A-C) GSEA reveals enrichment of the hypoxia signature in TNS4-high HNSCC tissues in TCGA HNSCC, GSE37991, and GSE47443. (D) Correlation between HIF1A and TNS4 expression across multiple independent HNSCC cohorts. (E-F) Temporal dynamics of TNS4 mRNA expression under hypoxic conditions at indicated time points. (G-H) Temporal dynamics of TNS4 protein expression under hypoxic conditions at indicated time points. (I) HIF-1α binding motif as identified by the JASPAR database. (J) Relative luciferase activities in SCC-1 cells subjected to indicated treatments. (K) ChIP-qPCR analysis showing the enrichment of HIF-1α at the TNS4 promoter region. (L-M) Impact of HIF-1α depletion on TNS4 expression in HNSCC cells under normoxic and hypoxic conditions.