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The role of PROK1 in pregnant related disease
| Disease | Abnormal expression of PROK1 | Functions of PROK1 | Reference |
|---|---|---|---|
| Pre-eclampsia | higher | Inhibit trophoblast invasion | 10,66, 67 |
| Recurrent miscarriage | lower | gene polymorphisms of PROK1 and PROKR1 are related to recurrent miscarriage | 15,70,71 |
| Recurrent implantation failure | higher | unclear | 72 |
| Fetal growth restriction |
high | Increase the angiogenesis and proliferation of placental villi | 73 |
