Table 2.

Circulating sPD-1 and sPD-L1 levels of study patients according to baseline characteristics.

Characteristic	sPD-1		sPD-L1
	Median [IQR], pg/ml	p	Median [IQR], pg/ml	p
Age (years)   ≥70  <70	185 [142–276] 148 [93–228]	<0.01	260 [230–318] 234 [184–298]	0.02
Sex   Female  Male	166 [119–264] 169 [112–257]	0.78	235 [190–279] 258 [218–319]	0.02
ECOG performance status   ≥2  0 or 1	203 [148–284] 163 [111–246]	0.11	302 [261–369] 241 [204–300]	0.02
No. of previous regimens   ≥2  0 or 1	188 [136–320] 164 [109–235]	0.07	256 [220–329] 247 [204–302]	0.33

sPD-1, soluble programmed cell death–1; sPD-L1, soluble programmed cell death–ligand 1; IQR, interquartile range.

The p values were determined with the Wilcoxon ranked sum test.