Table 7.
Fixed effects estimates for comparison within the treatment group of HR, RMSSD and SDNN values from the first 2 h between baseline and following single oral administration of cannabidiol (CBD) paste in three escalating doses (0.2mg CBD/kg; 1mg CBD/kg; 3mg CBD/kg).
| Parameter | Regression coefficient (β) | 95% confidence intervals (CI) | Standard error (SE) | p-value |
|---|---|---|---|---|
| HR (bpm) | ||||
| Intercept | 42.5 | 40.6, 44.4 | 1.0 | < 0.001 |
| Baseline values | Reference | |||
| Trial 1 (0.2 mg CBD/kg) | 3.4 | 0.3, 6.6 | 1.6 | 0.034 |
| Trial 2 (1 mg CBD/kg) | 0.9 | −2.7, 4.5 | 1.8 | 0.627 |
| Trial 3 (3 mg CBD/kg) | −0.4 | −2.9, 2.1 | 1.3 | 0.766 |
| RMSSD (ms) | ||||
| Intercept | 118.4 | 107.2, 120.5 | 5.6 | < 0.001 |
| Baseline values | Reference | |||
| Trial 1 (0.2 mg CBD/kg) | 25.0 | 8.8, 41.1 | 8.2 | 0.003 |
| Trial 2 (1 mg CBD/kg) | 16.6 | −1.8, 35.1 | 9.3 | 0.077 |
| Trial 3 (3 mg CBD/kg) | 7.7 | −5.1, 20.5 | 6.5 | 0.233 |
| SDNN (ms) | ||||
| Intercept | 112.4 | 99.2, 125.6 | 6.6 | < 0.001 |
| Baseline values | Reference | |||
| Trial 1 (0.2 mg CBD/kg) | 40.1 | 20.8, 59.4 | 9.8 | < 0.001 |
| Trial 2 (1 mg CBD/kg) | 3.0 | −19.0, 25.1 | 11.1 | 0.785 |
| Trial 3 (3 mg CBD/kg) | 21.3 | 6.0, 36.6 | 7.7 | 0.007 |
HR, heart rate; RMSSD, root mean square of successive R-R interval differences; SDNN, standard deviation of normal-to-normal R-R intervals; bpm, beats per minute; ms, milliseconds.