Table 3.
Univariable and multivariable logistic regression analysis of residual factors following LEEP procedure in CIN3 patients.
| Characteristics | Univariable analyses | Multivariable analyses | |||
|---|---|---|---|---|---|
| Total (N) | OR (95% CI) | p value | OR (95% CI) | p value | |
| ECC before LEEP | 436 | ||||
| Normal or inflammation | 266 | Reference | Reference | ||
| HSIL | 126 | 4.126 (2.636–6.457) | <0.001 | 1.103 (0.395–3.082) | 0.852 |
| LSIL | 44 | 2.455 (1.284–4.691) | 0.007 | 2.016 (0.564–7.207) | 0.281 |
| LEEP internal cutting margin | 436 | ||||
| Normal or inflammation | 234 | Reference | Reference | ||
| LSIL | 38 | 0.755 (0.356–1.600) | 0.464 | 1.325 (0.334–5.264) | 0.689 |
| HSIL | 164 | 1.994 (1.327–2.997) | <0.001 | 2.003 (0.793–5.055) | 0.141 |
| Post-LEEP follow-up HPV | 436 | ||||
| Negative | 201 | Reference | Reference | ||
| Positive | 94 | 20.577 (10.396–40.729) | <0.001 | 9.441 (3.170–28.120) | <0.001 |
| Other 12 positive | 73 | 19.145 (9.359–39.166) | <0.001 | 11.816 (3.909–35.717) | <0.001 |
| 16/18 positive | 68 | 213.714 (67.882–672.837) | <0.001 | 114.692 (23.947–549.298) | <0.001 |
| Post-LEEP follow-up TCT | 436 | ||||
| NILM | 187 | Reference | Reference | ||
| ASC-US | 102 | 12.900 (6.103–27.269) | <0.001 | 19.338 (4.682–79.879) | <0.001 |
| ASC-H | 71 | 60.844 (26.109–141.788) | <0.001 | 122.770 (25.414–593.086) | <0.001 |
| LSIL | 35 | 188.800 (49.239–723.931) | <0.001 | 191.158 (26.741–1366.505) | <0.001 |
| HSIL | 41 | 224.200 (58.886–853.611) | <0.001 | 335.274 (43.075–2609.637) | <0.001 |
| Gland involvement | 436 | ||||
| NO | 332 | Reference | Reference | ||
| Yes | 104 | 81.410 (29.042–228.210) | <0.001 | 68.742 (12.142–389.181) | <0.001 |
LEEP, loop electrosurgical excision procedure, TCT, Thinprep cytology test, NILM, Negative for intraepithelial lesion or malignancy, ASC-US, Atypical squamous cells of undetermined significance, ASC-H, Atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion, LSIL, Low-grade squamous intraepithelial lesion, HSIL, High-grade squamous intraepithelial lesion.