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. 2023 Dec 13;14:1289004. doi: 10.3389/fendo.2023.1289004

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Copyright © 2023 Wang, Zhang, Lehwald, Tao, Liu, Liu, Koh and Sylvester

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased fatty acid synthesis in Wnt+ mice under high fat diet. (A) Immunoblot shows a significant increase in the expression of fatty acid synthesis-related genes (SREBP-1 and its downstream targets ACC, AceCS1, and FASN) and a decrease in fatty acid oxidation gene (MCAD) in Wnt+ livers under HFD. mTOR and its downstream gene Phospho-S6K were significantly increased in Wnt+ mice in response to HFD. α-tubulin served as a loading control. Increased serum cholesterol (B), triglycerides (C), and glucose (D) levels were found in HFD-treated Wnt+ mice when compared to wildtype. WT Wild-type, HFD high fat diet. *p value<0.05, **p value<0.01.