Figure 1. Longitudinal progression of hippocampal volumes as a function of HS.

(A) HS groups defined as a function of HS staging including early and advanced stages (HS+ for those at stage>0)²³. (B) HS groups determined by the classical definition of the pathology, by which only advanced cases with severe cell loss are included within the HS+ group. (C) HS groups defined as a function of HS staging, compared within groups of high and low/intermediate ADNC. After including ADNC grouping in the statistical model, the effect of HS was still significant (F=30.7, p=.015), with lower volumes in HS+ compared to HS− patients at 11.75 years before death. (D) HS groups determined by the classical definition of the pathology, compared within ADNC burden groups, with the effect of HS remaining significant after including this variable (F=26.1, p=.006). ADNC: Alzheimer’s disease neuropathological change. HS: hippocampal sclerosis of aging.