Table 3.

Subgroup analyses for the hazard ratio of cancer according to trajectories of predicted lean mass from 2006 to 2010

	N	Low stable	Low increasing	Moderately stable: Decreasing	Moderately stable: Increasing	High stable	P for interaction
Gender							<0.001
Women	9325	Ref.	1.135 (0.850, 1.515)	0.770 (0.499, 1.189)	1.047 (0.765, 1.433)	1.077 (0.753, 1.541)
Men	35 046	Ref.	0.786 (0.679, 0.909)	0.885 (0.743, 1.056)	0.759 (0.647, 0.888)	0.714 (0.602, 0.848)
Age (years)							0.043
<45	10 312	Ref.	0.893 (0.552, 1.446)	0.716 (0.365, 1.389)	0.831 (0.505, 1.377)	0.604 (0.341, 1.068)
≥45	34 062	Ref.	0.855 (0.747, 0.979)	0.887 (0.752, 1.047)	0.859 (0.766, 0.978)	0.837 (0.814, 0.968)
Regular PA							0.028
No	38 090	Ref.	0.853 (0.740, 0.983)	0.860 (0.720, 1.028)	0.781 (0.669, 0.912)	0.743 (0.628, 0.878)
Yes	6284	Ref.	0.822 (0.598, 1.129)	0.949 (0.651, 1.383)	0.961 (0.692, 1.336)	1.025 (0.716, 1.467)
Sedentary time							0.940
<8	34 136	Ref.	0.842 (0.728, 0.974)	0.884 (0.738, 1.058)	0.770 (0.657, 0.902)	0.791 (0.668, 0.937)
≥8	10 238	Ref.	0.861 (0.647, 1.145)	0.836 (0.581, 1.203)	0.962 (0.713, 1.297)	0.762 (0.542, 1.071)
Obesity							0.241
No	17 201	Ref.	0.786 (0.663, 0.932)	0.991 (0.748, 1.313)	0.777 (0.617, 0.977)	0.649 (0.443, 0.971)
Yes	27 173	Ref.	1.008 (0.812, 1.253)	0.941 (0.754, 1.176)	0.924 (0.753, 1.134)	0.879 (0.717, 1.077)
Smoke							0.018
No	28 919	Ref.	0.744 (0.601, 0.923)	0.875 (0.674, 1.135)	0.716 (0.565, 0.907)	0.710 (0.549, 0.917)
Yes	15 455	Ref.	0.912 (0.775, 1.074)	0.869 (0.707, 1.068)	0.848 (0.729, 1.033)	0.824 (0.682, 0.995)
Alcohol use							0.028
No	27 433	Ref.	0.808 (0.686, 0.952)	0.858 (0.702, 1.048)	0.761 (0.599, 0.967)	0.708 (0.547, 0.917)
Yes	16 941	Ref.	0.906 (0.732, 1.120)	0.907 (0.692, 1.189)	0.835 (0.702, 0.992)	0.829 (0.688, 0.999)
hs‐CRP							0.646
<2	10 909	Ref.	0.797 (0.622, 1.002)	0.726 (0.533, 0.989)	0.712 (0.546, 0.928)	0.711 (0.537, 0.941)
≥2	33 465	Ref.	0.874 (0.780, 1.018)	0.951 (0.787, 1.149)	0.859 (0.728, 1.014)	0.829 (0.693, 0.999)