Figure 1.

Aged Gipr ^−/− mice exhibit a greater proportion of lean tissue mass and increases in muscle strength and mass. (A) Representative micro‐computed tomography images of whole body (left) and quantitative analysis of body composition (right) of 104‐week‐old Gipr ^+/+ and Gipr ^−/− mice. The red, green and yellow areas represent bone tissue, lean tissue and adipose tissue, respectively. Bars indicate 1 cm. Data were normalized to body weight. n = 11 mice per group. (B) Body weight, (C) plasma triglyceride, (D) grip strength and (E) weights of the tibialis anterior, extensor digitorum longus, soleus, gastrocnemius and quadriceps femoris muscles of 12‐week‐old Gipr ^+/+ and Gipr ^−/− mice and 84‐week‐old Gipr ^+/+ and Gipr ^−/− mice. The muscle weights are shown as the average value of bilateral muscle weights in each mouse. n = 5 mice per group. All data are presented as mean ± SEM. NS, not significant.