Table 1.
Population | Enriched population | Percent of live lineage− gate | Percent of parent gate | 1 / neurosphere initiation frequency |
---|---|---|---|---|
CD24−THY1−/lo | Radial glia, astrocytes | 13 | 13 | |
EGFR− | Outer radial glia (oRG) | 4.3 | 33 | 104 |
EGFRmid | Ventricular radial glia (vRG) | 4.0 | 31 | 11.7 |
EGFRhi | 4.0 | 31 | 4.5 | |
EGFR+CXCR4+ | Astrocytes | 0.6 | 4.7 | 38 |
CD24+THY1−/lo | Neurons | 86 | 86 | |
CXCR4−EGFR+ | Early excitatory neurons | 5.2 | 6.3 | 61 |
CXCR4−EGFR− | Late excitatory neurons | 59 | 69 | ∞ |
CXCR4+ | Inhibitory neurons | 22 | 25 | ∞ |
THY1hi | Oligodendrocyte lineages | 1.2 | 1.2 | |
EGFR+PDGFRA− | Glial progenitor cells (GPCs) | 0.19 | 16 | 9.8 |
EGFR+PDGFRA+ | Pre-OPCs | 0.12 | 10 | 5.6 |
EGFR−PDGFRA+ | OPCs | 0.49 | 41 | 872 |
EGFR−PDGFRA− | Oligodendrocytes | 0.40 | 33 | 1634 |
Values are approximate.