Table 2.
Population | Enriched population | Engraft? | Percent GFAP + | Percent OLIG2+ | Percent DCX+ |
---|---|---|---|---|---|
CD24−THY1−/lo | Radial glia, astrocytes | ||||
EGFR− | Outer radial glia (oRG) | Yes | 87 | 13 | <1 |
EGFR+ | Ventricular radial glia (vRG) | Yes | 82 | 18 | <1 |
EGFR+CXCR4+ | Astrocytes | Yes | 100 | 0 | 0 |
CD24+THY1−/lo | Neurons | ||||
CXCR4−EGFR+ | Early excitatory neurons | Not tested | |||
CXCR4−EGFR− | Late excitatory neurons | No | — | — | — |
CXCR4+ | Inhibitory neurons | No | — | — | — |
THY1hi | Oligodendrocyte lineages | ||||
EGFRhiPDGFRA− | Glial progenitor cells (GPCs) | Yes | 33 | 67 | 0 |
EGFR+PDGFRA+ | Pre-OPCs | Yes | 0 | 100 | 0 |
EGFR−PDGFRA+ | OPCs | Yes | 0 | 100 | 0 |
EGFR−PDGFRA− | Oligodendrocytes | No | — | — | — |
Values represent percentage of human cells (marked by anti-human cytoplasmic antigen) that also stained positive for each lineage marker.