Table 1. General Characteristics of the ISARIC Cohort of Patients With Severe COVID-19 by World Health Organization Geographic Region.
| Characteristic | Patients, No. (%) | ||||||
|---|---|---|---|---|---|---|---|
| Global | Africa | Americas | Eastern Mediterranean | Europe | South-East Asia | Western Pacific | |
| Demographic characteristic | |||||||
| Total | 434 851 (100) | 221 529 (50.9) | 14 167 (3.3) | 9345 (2.1) | 180 185 (41.4) | 8033 (1.8) | 1592 (0.4) |
| Age | |||||||
| Available | 431 806 (99.3) | 221 467 (100) | 14 142 (99.8) | 9345 (100) | 177 227 (98.4) | 8033 (100) | 1592 (100) |
| Median (IQR), y | 61.0 (48.0-74.0) | 57.0 (45.0-68.0) | 60.0 (47.0-71.0) | 60.0 (49.0-70.0) | 69.0 (55.0-81.0) | 58.0 (46.0-69.0) | 59.0 (48.0-68.0) |
| Sex | |||||||
| Available | 434 851 (100) | 221 529 (100) | 14 167 (100) | 9345 (100) | 180 185 (100) | 8033 (100) | 1592 (100) |
| Female | 203 848 (46.9) | 116 167 (52.4) | 5493 (38.8) | 3434 (36.7) | 75 527 (41.9) | 2652 (33.0) | 575 (36.1) |
| Male | 230 664 (53.0) | 105 282 (47.5) | 8653 (61.1) | 5907 (63.2) | 104 429 (58.0) | 5380 (67.0) | 1013 (63.9) |
| Unknown | 339 (0.1) | 80 (0.0) | 21 (0.1) | 4 (0.0) | 229 (0.1) | 1 (0.0) | 4 (0.3) |
| Severity indicator | |||||||
| Received oxygen | |||||||
| Available | 434 782 (100) | 221 529 (100) | 14 167 (100) | 9345 (100) | 180 118 (100) | 8033 (100) | 1590 (99.9) |
| Yes | 404 942 (93.1) | 199 266 (90.0) | 13 354 (94.3) | 9317 (99.7) | 173 574 (96.4) | 7935 (98.8) | 1496 (94.1) |
| Treated in ICU | |||||||
| Available | 432 095 (99.4) | 221 528 (100) | 14 157 (99.9) | 9345 (100) | 177 440 (98.5) | 8033 (100) | 1592 (100) |
| Yes | 164 160 (38.0) | 86 842 (39.2) | 9631 (68.0) | 9343 (100) | 49 661 (28.0) | 7626 (94.9) | 1057 (66.4) |
| Comorbidity | |||||||
| Hypertension | |||||||
| Available | 350 101 (80.5) | 174 692 (78.9) | 13 696 (96.7) | 9313 (99.7) | 143 552 (79.7) | 7705 (95.9) | 1143 (71.8) |
| Yes | 156 204 (44.6) | 76 207 (43.6) | 7065 (51.6) | 4423 (47.5) | 64 914 (45.2) | 3034 (39.4) | 561 (49.1) |
| Diabetes | |||||||
| Available | 360 380 (82.9) | 166 526 (75.2) | 13 936 (98.4) | 9238 (98.9) | 161 411 (89.6) | 7696 (95.8) | 1573 (98.8) |
| Yes | 101 888 (28.3) | 45 657 (27.4) | 7793 (55.9) | 2103 (22.8) | 44 309 (27.5) | 1526 (19.8) | 500 (31.8) |
| HIV infection | |||||||
| Available | 342 066 (78.7) | 157 790 (71.2) | 11 648 (82.2) | 8522 (91.2) | 156 515 (86.9) | 6277 (78.1) | 1314 (82.5) |
| Yes | 14 225 (4.2) | 13 475 (8.5) | 119 (1.0) | 2 (0.0) | 603 (0.4) | 21 (0.3) | 5 (0.4) |
| Asthma | |||||||
| Available | 351 830 (80.9) | 158 263 (71.4) | 13 861 (97.8) | 9327 (99.8) | 161 090 (89.4) | 7707 (95.9) | 1582 (99.4) |
| Yes | 31 782 (9.0) | 7624 (4.8) | 1294 (9.3) | 409 (4.4) | 22 199 (13.8) | 129 (1.7) | 127 (8.0) |
| Chronic pulmonary disease | |||||||
| Available | 350 751 (80.7) | 154 864 (69.9) | 13 876 (97.9) | 9326 (99.8) | 163 390 (90.7) | 7713 (96.0) | 1582 (99.4) |
| Yes | 33 413 (9.5) | 3969 (2.6) | 1291 (9.3) | 159 (1.7) | 27 584 (16.9) | 338 (4.4) | 72 (4.6) |
| Obesity | |||||||
| Available | 227 973 (52.4) | 54 513 (24.6) | 8491 (59.9) | 9299 (99.5) | 146 818 (81.5) | 7322 (91.1) | 1530 (96.1) |
| Yes | 42 506 (18.6) | 11 957 (21.9) | 2559 (30.1) | 171 (1.8) | 27 393 (18.7) | 193 (2.6) | 233 (15.2) |
| Tuberculosis | |||||||
| Available | 201 270 (46.3) | 156 180 (70.5) | 10 209 (72.1) | 9314 (99.7) | 17 253 (9.6) | 7697 (95.8) | 617 (38.8) |
| Yes | 4229 (2.1) | 3981 (2.5) | 72 (0.7) | 27 (0.3) | 78 (0.5) | 64 (0.8) | 7 (1.1) |
Abbreviations: ICU, intensive care unit; ISARIC, International Severe Acute Respiratory and Emerging Infections Consortium.