Table 3.

Adverse events in CTN012 in the multivariable models (N = 821).

	With 1+ AEa	With 1+ ED visit	With 1+ Hospitalization
	Odds (95% CI)	Odds (95% CI)	Odds (95% CI)
Treatment period
Pre-COVID	Ref.	Ref.	Ref.
Post-COVID	0.81 (0.54–1.22)	0.91 (0.49–1.67)	0.78 (0.47–1.29)
Age
<40	Ref.	Ref.	Ref.
≥40	0.57 (0.36–0.90)b	0.72 (0.36–1.44)	0.59 (0.33–1.07)
Gender
Male	Ref.	Ref.	Ref.
Female	1.00 (0.66–1.53)	1.05 (0.54–2.03)	1.44 (0.85–2.44)
Race
White	Ref.	Ref.	Ref.
African American	1.31 (0.62–2.78)	1.81 (0.59–5.57)	1.64 (0.69–3.91)
Asian, Native Hawaiian or Pacific Islander, American Indian or Alaskan Native	1.50 (0.52–4.30)	2.13 (0.57–8.03)	2.58 (0.78–8.54)
Other	1.19 (0.44–3.21)	1.32 (0.30–5.75)	1.39 (0.46–4.21)
Ethnicity
Hispanic	Ref.	Ref.	Ref.
Non-Hispanic	0.93 (0.40–2.17)	0.88 (0.27–2.91)	0.66 (0.26–1.71)
Missing	0.39 (0.13–1.15)	0.25 (0.06–1.00)	0.51 (0.14–1.81)
Housing
Secure housing	Ref.		Ref.
Homeless/unstable/other/missing	2.16 (1.43–3.26)d		2.32 (1.37–3.93)c

Ref. = Reference group.

^aAdverse events include overdose, ED visit, Inpatient hospitalization, intoxication/altered mental status, criminal justice involvement.

^bDifferences among groups at p < 0.05.

^cp < 0.01.

^dp < 0.001.