Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 1;33(1):e4840. doi: 10.1002/pro.4840

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors. Protein Science published by Wiley Periodicals LLC on behalf of The Protein Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Schematic model of p62/SQSTM1 regulation by a LIR‐accessibility mechanism (LAM). p62/SQSTM1 is represented in equilibrium between populations of conformations hiding the LIR‐sequence (Left) and conformations exposing LIR‐sequence. Post‐translational modification of the ZZ domain or direct interaction with small compounds produce a change in the population of p62/SQSTM1 molecules enhancing the exposure of the LIR‐sequence, in turn favoring the interaction with LC3 at the early phagosome.