Table 4.
Baseline-independent factors predicting intragender 18-week survival among patients with HIV-associated cryptococcal meningitis on antifungal therapy.
| Variables Cytokines, Log2 (Pg/mL) |
Women Odds ratio estimate (95% CI for profile likelihood) |
P-value | Men Odds ratio estimate (95% CI for profile likelihood) |
P-value |
|---|---|---|---|---|
| Survival at 18 weeks, N (%) | 71 of 150 (47.3) | 136 of 230 (59.1) | 0.024 | |
| N (range)/model | Survived (n = 63 to n = 70) Died (n = 60 to n = 71) |
Survived (n = 118 to n = 131) Died (n = 78 to n = 91) |
||
| Model 1: survival adjusted for cytokine | ||||
| CCL11/Eotaxin | 0.42 (0.20–0.80) | 0.014 | 1.65 (1.00–2.76) | |
| CXCL10/-IP-10 | 0.48 (0.27–0.79) | 0.006 | 1.03 (0.76–1.40) | |
| IL-8/CXCL8 | 0.93 (0.65–1.31) | 1.38 (1.03–1.88) | 0.034 | |
| IL-15 | 0.96 (0.57–1.62) | 1.88 (1.20–3.04) | 0.007 | |
| Model 2: survival adjusted for age, weight, systolic blood pressure and cytokines | ||||
| CCL11/Eotaxin | 0.35 (0.16–0.69) | 0.005 | 1.55 (0.94–2.60) | |
| CXCL10/IP-10 | 0.55 (0.30–0.96) | 0.042 | 1.00 (0.73–1.37) | |
| IL-10 | 2.26 (1.00–5.11) | 0.044 | 0.65 (0.32–1.27) | |
| IL-15 | 0.86 (0.48-1.50) | 1.63 (1.03–2.64) | 0.040 | |
| Model 3: survival adjusted for hemoglobin, platelets count, CD4 counts, and cytokines | ||||
| CD4 T-cell counts/µL | 0.99 (0.98–1.00) | 0.039 | 1.00 (0.99–1.01) | |
| IL-2 | 1.94 (1.13–3.78) | 0.025 | 0.59 (0.30–1.06) | |
| IL-10 | 2.33 (1.04–5.39) | 0.038 | 0.73 (0.34–1.51) | |
| CCL11/Eotaxin | 0.29 (0.12–0.63) | 0.004 | 1.044 (0.970–1.129) | |
| CXCL10/IP-10 | 0.45 (0.25–0.76) | 0.004 | 0.98 (0.69–1.38) | |
| IL-8/CXCL8 | 0.92 (0.64–1.32) | 1.69 (1.17–2.58) | 0.009 | |
| IL-15 | 0.81 (0.43–1.49) | 1.79 (1.05–3.20) | 0.041 | |
| Hemoglobin, g/dL | 0.82 (0.66–1.02) | 0.82 (0.70–0.94) | 0.006 | |
| Model 4: survival adjusted for sodium, potassium, and cytokines | ||||
| CCL11/Eotaxin | 0.32 (0.12–0.70) | 0.009 | 1.74 (1.01–3.05) | 0.048 |
| CXCL10/IP-10 | 0.52 (0.27–0.92) | 0.033 | 1.10 (0.79–1.55) | |
| IL-8/CXCL8 | 0.87 (0.59–1.28) | 1.41 (1.02–2.00) | 0.044 | |
| IL-15 | 0.89 (0.48–1.66) | 2.36 (1.43–4.12) | 0.001 | |
| Sodium, mmol/L | 0.96 (0.88–1.04) | 0.87 (0.93–0.98) | 0.011 | |
| Potassium, mmol/L | 0.49 (0.24–0.95) | 0.044 | 0.99 (0.62–1.59) | |
Multivariate adjusted models of gender-specific associated factors (univariate gender-specific survival–associated factors in Table 5 ) were interrogated with statistically different gender-associated demographic variables ( Table 1 ). Odds ratios represent the independent likelihood of survival based on levels of the indicated factor with an adjusted multivariate logistic regression model. Statistic: intragender (male or female) multiple logistic regression. Not statistically significant variables had adjusted p-value ≥0.05 at a 95% confidence interval.