Extended Data Fig. 8. The effect of an A₁R antagonist on dSPNs and iSPNs.

a & b, Collective changes of basal and enforced running-induced PKA activity, as indicated, in dSPNs (a) and iSPNs (b) in response to the intraperitoneal injection of the A₁ receptor antagonist DPCPX (2 mg/kg). n (neurons/mice) = 55/5 for dSPNs and 118/6 for iSPNs. Two-tailed paired Student’s t-test, from left to right across panels, p = 8.4×10⁻¹¹, 0.0029, 3.9×10⁻⁴, and 0.42; dF = 54, 54, 117, and 117; t = −8.0, −3.1, −3.7, and 0.8. All error bars represent SEM and their centers represent the mean. n.s.: p > 0.05; **: p ≤ 0.01; ***: p ≤ 0.001.