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. Author manuscript; available in PMC: 2023 Dec 27.
Published in final edited form as: Nature. 2022 Nov 9;611(7937):762–768. doi: 10.1038/s41586-022-05407-4

Extended Data Fig. 2. tAKARα response to pharmacological manipulations depends on sensor phosphorylation.

Extended Data Fig. 2.

a & b, Collective responses of tAKARα (snsr) and its phosphorylation-deficient mutant (mut.) to the indicated drug application in dSPNs (a) and iSPNs (b). From left to right, n (neurons/mice) = 38/6, 54/4, 38/6, and 41/4 for dSPNs, and 63/8, 57/4, 63/8, and 60/4 for iSPNs. Two-tailed unpaired Student’s t-test for both panels, from left to right, p = 1.7×10−21, 0.029, 6.0×10−6, and 2.0×10−12; dF = 90, 77, 118, and 121; t = 12.6, 2.2, 4.7, and −7.8. All error bars represent SEM and their centers represent the mean. *: p ≤ 0.05; ***: p ≤ 0.001.