TABLE 3.

Depressive Disorder at 3-Year Follow-Up and Node Strength of all Reward Network Nodes in a Study of Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder^a

Node	Odds Ratio	95% CI	P
Striatal node strength
Left ventral striatum	1.54	1.09–2.18	0.015b
Right ventral striatum	1.23	0.83–1.82	0.311
Other regions from the reward network
Ventromedial prefrontal cortex	0.81	0.41–1.59	0.534
Left anterior insula	1.21	0.76–1.66	0.569
Right anterior insula	1.33	0.90–1.98	0.162
Posterior cingulate	1.16	0.48–2.85	0.742
Brainstem (ventral tegmental area)	0.93	0.56–1.55	0.775
Anterior cingulate	1.02	0.65–1.58	0.948
Pre-supplementary motor area	1.18	0.76–1.84	0.452
Left thalamus	1.03	0.64–1.65	0.904
Right thalamus	1.16	0.72–1.87	0.542

^aExposed, N=529; event, N=56. All models controlled for sex, age, site, number of scrubbed volumes, and the following psychiatric disorders at baseline: any anxiety disorder, attention deficit hyperactivity disorder, and depressive disorder.

^bCorrected for striatum laterality (p/2), p=0.03.