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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Metabolism. 2023 May 23;145:155591. doi: 10.1016/j.metabol.2023.155591

Figure 3. Knockdown of T-KHK in mice on HFD+F diet profoundly alters hepatic transcriptome.

Figure 3.

A) Principal component analysis (PCA) of RNAseq data from the livers of mice presented in figure two. B) The most significantly altered pathways from this analysis. Volcano plot analysis in HFD+F-fed mice showing upregulated and downregulated genes with KHK knockdown (siKHK) compared to HFD+F/PBS control. Some of the most altered genes are labeled in C) and in D) are labeled the genes involved in ER stress. mRNA expression of genes regulating E) ribosomal subunits (Rplp0,Rplp1,Rplp2,Rpl5) and de novo lipogenesis (Acly, Acc1, Fasn, Scd1).