Table 3.
Relationship between the expression of six hub genes and the infiltration levels of cells in the TME.
| Hub genes | Purity | CD8+ T cell | CD4+ T cell | B cell | DC cell | NK cell | Macrophages | CAF | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| COR | P-value | COR | P-value | COR | P-value | COR | P-value | COR | P-value | COR | P-value | COR | P-value | COR | P-value | |
| ALPK2 | –0.519 | 1.24e-18 | 0.203 | 1.26e-03 | –0.055 | 0.391 | –0.187 | 3.12e-03 | –0.005 | 0.936 | 0.302 | 1.23e-06 | 0.243 | 1.08e-04 | 0.803 | 1.69e-57 |
| FAP | –0.595 | 2.77e-25 | 0.196 | 1.85e-03 | –0.045 | 0.479 | –0.222 | 4.05e-04 | 0.035 | 0.583 | 0.325 | 1.62e-07 | 0.238 | 1.50e-04 | 0.830 | 1.45e-64 |
| SFRP2 | –0.500 | 3.04e-17 | 0.190 | 2.64e-03 | –0.094 | 0.137 | –0.245 | 9.50e-05 | –0.064 | 0.313 | 0.238 | 1.55e-04 | 0.244 | 1.02e-04 | 0.736 | 8.27e-44 |
| GATA4 | 0.138 | 0.0289 | –0.125 | 0.0494 | 0.044 | 0.489 | 0.025 | 0.691 | –0.140 | 0.027 | –0.290 | 3.32e-06 | –0.208 | 9.45e-04 | –0.237 | 1.59e-04 |
| STAR | 0.281 | 6.61e-06 | –0.179 | 4.65e-03 | 0.091 | 0.151 | 0.040 | 0.526 | –0.138 | 0.0298 | –0.297 | 1.88e-06 | –0.200 | 1.52e-03 | –0.300 | 1.46e-06 |
| TSPAN8 | 0.224 | 3.57e-04 | –0.115 | 0.0698 | 0.011 | 0.862 | 0.001 | 0.993 | –0.105 | 0.0984 | –0.330 | 1.02e-07 | 0.007 | 0.917 | –0.324 | 1.7e-07 |
CAF: Cancer associated fibroblasts; CD4: Cluster of differentiation 4; COR: Correlation coefficient; DC: Dendritic cells; NK: natural killer; TME: Tumor environment.