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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Nat Neurosci. 2023 Jun 8;26(7):1229–1244. doi: 10.1038/s41593-023-01350-3

Extended Data Fig. 2 |. NAc RNA-seq deconvolution across injury and withdrawal conditions.

Extended Data Fig. 2 |

a–c. RNA-seq deconvolution of Sham-Oxy vs Sham-Saline, SNI-Saline vs Sham Saline, and SNI-Oxy vs Sham-Saline, respectively (n = 4 per group), demonstrating condition-specific alterations in transcriptomic representations of neuronal and vascular cell subtypes (Sham-Oxy vs Sham-Sal Neuron_1 unpaired t-test, t = 2.595, df=6, p = 0.0409; SNI-Sal vs Sham-Sal Mural unpaired t-test, t = 2.456, df=6, p = 0.0494, Neuron_1 unpaired t-test, t = 2.042, df=6, p = 0.0873, Microglia Welch’s unpaired t-test, t = 2.818, df=3.328, p = 0.0593; SNI-Oxy vs Sham-Sal unpaired t-test, t = 2.025, df=6, p = 0.0893). Values are represented as mean ± SEM *p < 0.05.