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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Nat Neurosci. 2023 Jun 8;26(7):1229–1244. doi: 10.1038/s41593-023-01350-3

Extended Data Fig. 5 |. Additional affective behaviors after treatment with RBC1HI.

Extended Data Fig. 5 |

a. Habituation phase of Sham-Sal male mice after receiving Veh or RBC1HI, demonstrating equal interaction times for two empty cups (Sham-Sal-Veh n = 9, Sham-Sal-RBC1HI n = 10). b. RBC1HI and Veh animals both showed a preference for social targets in the sociability phase of the social interaction assay (Sham-Sal-Veh n = 8, Sham-Sal-RBC1HI n = 9). c. Female mice undergoing spontaneous withdrawal from oxycodone bury fewer marbles after longitudinal RBC1HI treatment (Sham-Oxy-Veh n = 6, Sham-Oxy-RBC1HI n = 7; unpaired t-test t = 3.663, df=11, p = 0.0037). Values are represented as meant ± SEM **p < 0.01, ****p < 0.0001.