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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Nat Neurosci. 2023 Jun 8;26(7):1229–1244. doi: 10.1038/s41593-023-01350-3

Fig. 4 |. Predicted biological processes and transcriptional regulators altered by oxycodone withdrawal with chronic neuropathic pain and pain-free states.

Fig. 4 |

a,d,g, Venn diagrams depicting overlap of genes altered by oxycodone withdrawal under SNI-Oxy versus SNI-Sal and in Sham-Oxy versus Sham-Sal conditions in the NAc (a), mPFC (d) and VTA (g). These graphs also show respective union heat maps of commonly regulated DEGs between SNI-Oxy versus SNI-Sal and Sham-Oxy versus Sham-Sal conditions in the NAc, mPFC and VTA, as well as associated GO terms or predicted drug targets. b,c,e,f,h,i, Top predicted URs of Sham-Oxy versus Sham-Sal and SNI-Oxy versus SNI-Sal DEGs in the NAc (b and c), mPFC (e and f) and VTA (h and i). Top predicted URs of SNI-Oxy versus Sham-Sal control DEGs in NAc, mPFC and VTA.