表 2. Univariate and multivariate Cox analyses of IgAN patients with stage 3-4 CKD.
CKD 3-4期IgAN患者的单因素和多因素Cox分析
| Characteristic | Univariate Cox | Multivariate Cox (UA as continuous variable) |
Multivariate Cox (UA as dichotomous variables) |
|||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||
| BMI: body mass index; NLR: neutrophil to lymphocyte ratio; Hb: hemoglobin; IB: indirect bilirubin; HUA: high uric acid; AST: aspartate aminotransferase. 1 The Oxford classification denotes the same as that in Table 1. | ||||||||
| Age | 0.96 (0.95-0.98) | <0.001 | 0.97 (0.95-0.99) | 0.002 | 0.97 (0.95-0.99) | <0.001 | ||
| BMI | 0.94 (0.90-0.99) | 0.026 | ||||||
| WBC | 1.07 (1.00-1.15) | 0.044 | ||||||
| Hb | 0.98 (0.98-0.99) | <0.001 | ||||||
| AST | 0.97 (0.95-1.00) | 0.048 | ||||||
| IB | 0.91 (0.85-0.97) | 0.005 | ||||||
| Blood urea nitrogen | 1.15 (1.11-1.20) | <0.001 | ||||||
| HUA (as dichotomous variables) | 2.42 (1.69-3.46) | <0.001 | 1.61 (1.10-2.34) | 0.013 | ||||
| HUA (as continuous variable) | 1.28 (1.17-1.40) | <0.001 | 1.18 (1.08-1.29) | <0.001 | ||||
| Serum potassium | 2.21 (1.59-3.07) | <0.001 | 1.46 (1.04-2.06) | 0.03 | ||||
| eGFR | 0.93 (0.91-0.95) | <0.001 | 0.93 (0.91-0.95) | <0.001 | 0.92 (0.90-0.94) | <0.001 | ||
| Glomeruli sclerosis ratio | 1.02 (1.01-1.03) | <0.001 | ||||||
| Hypertension | 1.97 (1.3-2.99) | 0.002 | ||||||
| Treatment immunosuppressants |
0.66 (0.46-0.95) | 0.024 | ||||||
| Oxford classification1 | ||||||||
| M1 | 2.17 (1.46-3.23) | <0.001 | 1.71 (1.11, 2.64) | 0.015 | 1.83 (1.19, 2.80) | 0.006 | ||
| S1 | 2.92 (1.36-6.27) | 0.006 | ||||||
| T1 | 3.28 (1.65-6.53) | 0.001 | 2.78 (1.36, 5.68) | 0.005 | 2.79 (1.37, 5.68) | 0.005 | ||
| T2 | 5.69 (2.93-11.08) | <0.001 | 1.96 (0.95, 4.02) | 0.067 | 1.88 (0.92, 3.84) | 0.083 | ||