. Author manuscript; available in PMC: 2025 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Nov 21;44(1):24–47. doi: 10.1161/ATVBAHA.123.320138

Table 7:

Population-based studies providing assessing the association of aortic diameter with future cardiovascular events and death

Study [ref]	Country, Year of publication	Population (% men, mean age)	Follow-up (years)	Outcome (n=)	Measurement	Adjusted HR (95% CI)^*	Ethnicity and/or other comments
Framingham¹⁵⁶	USA 2017	3318 (51%, 50y)	8.8	Adverse CV events (177)	CT Ascending Descending Infrarenal Above bifurcation	Ascending: No assoc. Descending: No robust assoc. Infrarenal: 1.57 [1.06–2.32] Above bifurcation 1.53 [1.00–2.34]	10.1161/CIRCIMAGING.117.006776 Data shown after adjusting for FRS factors model 2 Possible sex-specific effects for abdominal aortic diameters. Similar results after adjusting for CAC. Analyses for both top 10% and continuous
Rotterdam ¹⁵⁷	Holland 2022	2178 (45%, 69y)	9	CVD (85) stroke (128)	CT diameters adjusted for BMI Ascending Descending	Ascending 1.33 [1.03–1.73] Descending1.38 [1.07–1.78]	Results for women only, no association in men

AP, anterior-posterior; CV, cardiovascular; CVD, cardiovascular death; ITI inner-to-inner aortic wall; OTO outer-to-outer aortic wall; FRS Framingham risk score.

This supersedes the earlier 2012 study of <9000 men by Duncan et al where no associations with CVD were identified. ¹⁵⁸