Table 1 –
Baseline study population characteristics stratified by malnutrition status
| Characteristic, n (%) | Overall, N = 231 | Malnutrition Absent (MNA-SF Score > 11), N = 134 | Malnutrition Present (MNA-SF Score ≤ 11), N = 97 | P-value |
|---|---|---|---|---|
| Socio-demographics | ||||
| Age in years, median (IQR) | 73 (64, 81) | 74 (68, 80) | 72 (60, 82) | 0.19 |
| Women | 152 (65.8%) | 87 (64.9%) | 65 (67.0%) | 0.74 |
| White Race | 170 (73.6%) | 92 (68.7%) | 78 (80.4%) | 0.045 |
| Non-White Race | 61 (26.4%) | 42 (31.3%) | 19 (19.6%) | |
| Hispanic Ethnicity | 19 (8.2%) | 12 (9.0%) | 7 (7.2%) | 0.26 |
| Comorbid conditions | ||||
| Coronary Artery Disease | 64 (27.7%) | 37 (27.6%) | 27 (27.8%) | 0.97 |
| Atrial Fibrillation | 99 (42.9%) | 62 (46.3%) | 37 (38.1%) | 0.22 |
| Diabetes Mellitus | 96 (41.6%) | 52 (38.8%) | 44 (45.4%) | 0.32 |
| Hypertension | 186 (80.5%) | 108 (80.6%) | 78 (80.4%) | 0.97 |
| COPD | 48 (20.8%) | 26 (19.4%) | 22 (22.7%) | 0.54 |
| Current Smoker | 5 (2.2%) | 2 (1.5%) | 3 (3.1%) | 0.65 |
| Obesity | 146 (63.2%) | 86 (64.2%) | 60 (61.9%) | 0.72 |
| BMI in kg/m2, median (IQR) | 33 (27, 40) | 32 (28, 38) | 33 (27, 42) | 0.62 |
| Systolic BP in mmHg, median (IQR) | 130 (117, 142) | 134 (119, 148) | 124 (115, 138) | 0.004 |
| eGFR, median (IQR) | 62 (44, 80) | 63 (45, 82) | 59 (42, 79) | 0.39 |
| HF Characteristics | ||||
| Heart failure diagnosed within previous 18 months | 63 (27.3%) | 27 (20.1%) | 36 (37.1%) | 0.004 |
| NYHA Class | 0.53 | |||
| 1 | 7 (3.0%) | 4 (3.0%) | 3 (3.1%) | |
| 2 | 77 (33.3%) | 41 (30.6%) | 36 (37.1%) | |
| 3 | 138 (59.7%) | 85 (63.4%) | 53 (54.6%) | |
| 4 | 9 (3.9%) | 4 (3.0%) | 5 (5.2%) | |
| LVEF, median (IQR) | 62 (60, 67) | 62 (60, 67) | 61 (60, 67) | 0.87 |
| MAGGIC Score, median (IQR) | 22 (16, 26) | 21 (17, 26) | 22 (16, 27) | 0.73 |
| All-cause hospitalization within prior 6 months | 113 (48.9%) | 61 (45.5%) | 52 (53.6%) | 0.22 |
| Baseline medication use | ||||
| Beta Blocker | 135 (58.4%) | 74 (55.2%) | 61 (62.9%) | 0.24 |
| ACE-I/ARB | 86 (37.2%) | 57 (42.5%) | 29 (29.9%) | 0.050 |
| Diuretics | 186 (80.5%) | 104 (77.6%) | 82 (84.5%) | 0.19 |
| Statins | 157 (68.0%) | 96 (71.6%) | 61 (62.9%) | 0.16 |
BP: Blood Pressure; BMI: Body Mass Index; NYHA: New York Heart Association; COPD: Chronic Obstructive Pulmonary Disease; ACE-I: Angiotensin Converting Enzyme Inhibitor; ARB: Angiotensin Receptor Blocker; MAGGIC: Meta-Analysis Global Group in Chronic (MAGGIC) heart failure; LVEF: Left Ventricle Ejection Fraction; CAD: Coronary Artery Disease; CKD: Chronic Kidney Disease; IQR: Interquartile Range; eGFR: estimated glomerular filtration rate