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Sulfotransferases covered in this review. Sulfotransferases transfer a sulfo group (SO3) from PAPS, which is generated in the cytosol by the bifunctional PAPS synthases to many different types of acceptor substrates. The SULT enzymes in the cytosol sulfate endogenous and exogenous small molecules, whereas the Golgi-associated sulfotransferase sulfate macromolecules such as proteins and glycosaminoglycans.
