Table 1.

Representative structures of the human SULT, TPST, and HSSTs

Sulfotransferase	Acceptor	Nucleotide	PDB Code	Res Å	Reference
Human Cytosolic Sulfotransferases (SULTs)
SULT1A1	p-nitrophenol	PAP	1LS6	1.9	(Gamage et al., 2003)
	estradiol	PAP	2D06	2.3	(Gamage et al., 2005)
	p-nitrophenol	PAP	3QVU	2.5	(Alcolombri et al., 2011)
	3-cyanoumbelliferone	PAP	3QVV	2.35	(Alcolombri et al., 2011)
	2-napthol	PAP	3U3K	2.36	(Berger et al., 2011)
	3-cyano-7-hydroxycoumarin	PAP	3U3M, 3U3O	2.3, 2.0	(Berger et al., 2011)
	p-nitrophenol	PAP	3U3R	2.36	(Berger et al., 2011)
	—	PAP	3U3J	2.70	(Berger et al., 2011)
	—	PAP	4GRA	2.56	(Cook et al., 2013a)
SULT1A1*3	—	PAP	1Z28	2.3	(Lu et al., 2010)
SULT1A2		PAP	1Z29	2.4	(Lu et al., 2010)
SULT1A3	Dopamine	PAP	2A3R	2.6	(Lu et al., 2005)
	—	—	1CJM	2.4	(Bidwell et al., 1999)
SULT1B1	Resveratrol	PAP	3CKL	2.0	TBPf
	—	PAP	2Z5F	2.1	(Dombrovski et al., 2006)
SULT1C2a	—	PAP	3BFX	1.8	(Dombrovski et al., 2006)
SULT1C3d	—	PAP	2H8K	3.2	(Allali-Hassani et al., 2007)
	—	PAP	2REO	2.65	TBP
SULT1C4b	Pentrachlorophenol	PAP	2GWH	1.80	(Allali-Hassani et al., 2007)
	—	—	2AD1	2.00	(Allali-Hassani et al., 2007)
SULT1E1	Estradiol	PAP	4JVL	1.94	(Gosavi et al., 2013)
	Tetrabromobisphenol A	PAP	4JVM	1.99	(Gosavi et al., 2013)
	3,5,3′,5′-tetrachloro-biphenyl-4-4’-diol	PAP	1G3M	1.7	(Shevtsov et al., 2003)
	3-hydroxylbromodiphenyl ether	PAP	4JVN	2.05	(Gosavi et al., 2013)
	—	PAPS	1HY3	1.80	(Pedersen et al., 2002)
SULT2A1	Androsterone	—	1OV4	2.70	(Chang et al., 2004)
	DHEAg	—	1J99	1.99	(Rehse et al., 2002)
	(3Beta,5alpha)-3-Hydroxyandrostan-17-one	—	2QP32QP4	2.63.0	(Lu et al., 2008)
	Lithocholic acid	PAP	3F3Y	2.2	TBP
		PAPS	4IFB	2.3	TBP
	—	PAP	1EFH	2.4	(Pedersen et al., 2000)
SULT2B1a	—	PAP	1Q1Q	2.91	(Lee et al., 2003)
SULT2B1b	DHEA	PAP	1Q22	2.5	(Lee et al., 2003)
	Pregnenolone	PAP	1Q20	2.3	(Lee et al., 2003)
	—	PAP	1Q1Z	2.4	(Lee et al., 2003)
SULT4A1	—	—	1ZD1	2.24	(Allali-Hassani et al., 2007)
Tyrosyl Protein Sulfotransferase (TPSTs)
TPST-1	DFEDYEFD	PAP	5WRI	1.60	(Tanaka et al., 2017)
	EEEEEAYGWMDF	PAP	5WRJ	2.33	(Tanaka et al., 2017)
TPST-2	EDFEDYEFD		3AP1	1.9	(Teramoto et al., 2013)
	EDFEDYEFD	PAP	3AP2	2.4	TBP
	—	PAP	3AP3	3.5	(Teramoto et al., 2013)
Heparan Sulfate Sulfotransferases (HSSTs)
NDST-1 (sulfotransferase catalytic domain)	—	PAP	1NST		(Kakuta et al., 1999)
2-OSTc	GlcA-GlcNAc-GlcA-GlcNS-IdoAh-GlcNS-GlcA-pNP	PAP	4NDZ	3.45	(Liu et al., 2014)
	—	PAP	3F5F	2.65	(Bethea et al., 2008)
6-OST-3d	GlcNS-GlcA-GlcNS-IdoA2S-GlcNS-GlcA-pNP	PAP	5T05	1.95	(Xu et al., 2017b)
	GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-pNP	PAP	5T03	2.1	(Xu et al., 2017b)
	GlcA-GlcNS-GlcA-GlcNS-GlcA-GlcNS-GlcA-pNP	PAP	5T0A	1.95	(Xu et al., 2017b)
3-OST-1e	GlcNAc6S-GlcA-GlcNS6S-IdoA2S-GlcNS6S-GlcA-UA	PAP	3UAN	1.84	(Moon et al., 2012)
	—	PAP	1VKJ	2.5	(Edavettal et al., 2004)
3-OST-1	—	PAP	1ZRH	2.1	TBP
3-OST-3	GlcNAc-GlcA-GlcNS-Ido2S-GlcNS-Ido2S-GlcNS-GlcA-pNP	PAP	6XL8	2.34	(Wander et al., 2021)
	GlcNAc6S-GlcA-GlcNS6S-Ido2S-GlcNS6S-Ido2S-GlcNS6S-GlcA-pNP	PAP	6XKG	1.55	(Wander et al., 2021)
	δUA2S-IdoA2S-GlcNS6S-IdoA2S	PAP	1T8U	1.95	(Moon et al., 2004)
	—	PAP	1T8T	1.85	(Moon et al., 2004)
3-OST-5	—	PAP	3BD9	2.3	(Xu et al., 2008)

^aIn PDB under SULT1C1.

^bIn PDB under SULT1C2.

^c Gallus gallus.

^d Danio rerio.

^e Mus musculus.

^fTBP (To be published).

^gdehydroepiandrosterone.

^hacceptor saccharide is in bold.