Table 1.
Major drugs/targets and their effects on ferroptosis aimed at mitochondria.
| Drugs/reagents targeting mitochondria | Effect on ferroptosis | Role in diseases |
|---|---|---|
| STING1 | Promotion | / |
| MFN1/2 | Promotion | / |
| ROS | Promotion | / |
| Glutamine | Promotion | / |
| Glutamate | Promotion | / |
| α-KG | Promotion | / |
| PUFA hydroperoxide | Promotion | / |
| Cys | Promotion | / |
| Erastin | Promotion | / |
| KGDHC | Promotion | / |
| VDAC | Promotion | / |
| SLC7A11 | Promotion | / |
| Arsenic exposure | Promotion | Inducing acute lung injury |
| FUNDC1 | Promotion | Inducing liver injury |
| SSBP1 | Promotion | Inhibiting progression and migration of GBM cells |
| AC | Promotion | Exhibiting anti-tumor activity |
| COX7A1 | Promotion | / |
| Electron leakage site IIIQo inhibitors | Inhibition | / |
| ETC inhibitors | Inhibition | / |
| Mitochondrial uncoupling agents | Inhibition | / |
| MitoQ | Inhibition | / |
| Erythropoietin | Inhibition | / |
| DHODH | Inhibition | / |
| FoxO3a | Inhibition | / |
| AMPK | Inhibition | / |
| ACC | Inhibition | / |
| STARD7 | Inhibition | / |
| CoQ | Inhibition | / |
| GPD2 | Inhibition | / |
| Cannabidiol | Inhibition | / |
| N-acetylcysteine | Inhibition | / |
| NOX4 | Inhibition | Delaying Alzheimer’s disease |
| Ferrostatin-1 | Inhibition | Improving IIRI and UC |
| Desferrioxamine | Inhibition | Improving UC |