Table 2.

Association between LMM and risk of all-cause and CVD-specific mortality in cancer survivors and matched cohort

	No. death/person-years	Mortality rate (per 1,000 person-years) (95% CI)	Age-adjusted HR (95% CI)	aHR (95% CI)†	aHR (95% CI)‡
All-cause mortality
Cancer survivors (N=946)
Without LMM (N=736)	208/6,862.7	30.3 (26.5, 34.7)	REF	REF	REF
With LMM (N=210)	113/1,686.3	67.0 (55.7, 80.6)	1.63 (1.29, 2.06)	1.73 (1.31, 2.29)	1.66 (1.21, 2.28)
	overall: 321/8548.9	overall: 37.5 (33.7, 41.9)
Matched cohort (N=1,857)
Without LMM (N=1,492)	333/14,667.1	22.7 (20.4, 25.3)	REF	REF	REF
With LMM (N=365)	162/3,386.8	47.8 (41.0, 55.8)	1.29 (1.06, 1.57)	1.24 (0.98, 1.56)	1.24 (0.95, 1.63)
	overall: 495/18,053.9	overall: 27.4 (25.1, 29.9)
CVD-specific mortality
Cancer survivors (N=946)
Without LMM (N=736)	36/6,862.7	5.2 (3.8, 7.3)	REF	REF	REF
With LMM (N=210)	22/1,686.3	13.0 (8.6, 19.8)	1.64 (0.95, 2.81)	2.13 (1.14, 4.00)	2.46 (1.27, 4.74)
	overall: 58/8,548.9	overall: 6.8 (5.2, 8.8)
Matched cohort (N=1,857)
Without LMM (N=1,492)	82/14,667.1	5.6 (4.5, 6.9)	REF	REF	REF
With LMM (N=365)	40/3,386.8	11.8 (8.7, 16.1)	1.25 (0.85, 1.85)	1.21 (0.75, 1.93)	1.22 (0.72, 2.06)
	overall: 122/18,053.9	overall: 6.8 (5.7, 8.1)

Abbreviations: aHR: adjusted hazard ratio, CI: confidence interval, CVD: cardiovascular disease

^†The model adjusted for age, sex, race, education, marital status, smoking status, relative fat mass, energy intake, physical exercise, burden of comorbidities, history of more than 1 cancer (for survivors). For cancer survivors, the model was stratified by time elapse since cancer diagnosis and smoking status when outcome was all-cause mortality.

^‡The model adjusted for the same set of covariate and was corrected for NHANES sampling weight